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Article

cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53

13 Jul 2018

Abstract excerpt

model of the most common form of childhood cancer, B cell precursor acute lymphoblastic leukemia (BCP-ALL), to show that activation of the cAMP signaling pathway inhibits p53-mediated apoptosis in response to DNA damage in both cell lines and primary leukemic cells. The present study reveals that cAMP-mediated survival of BCP-ALL cells exposed to DNA damaging agents, involves a critical and p53-independent...

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PMID: 30100998
DOI: 10.18632/oncotarget.25758

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