Article

A carotenoid-enriched extract from pumpkin delays cell proliferation in a human chronic lymphocytic leukemia cell line through the modulation of autophagic flux

2020-05-27

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most frequent form of leukemia in the adult population. From an asymptomatic state, which can lay for years, CLL rapidly evolves becoming fatal. Apoptosis resistance and induction of a protective form of autophagy are possible explanations of the poor responsivity of CLL to conventional and innovative therapeutic drugs. Carotenoids, including α- and β-carotene, lycopene, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 596da242-e0b8-5830-9d03-50e8e8c07e31
DOI: 10.1016/j.crbiot.2020.05.001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A carotenoid-enriched extract from pumpkin delays cell proliferation in a human chronic lymphocytic leukemia cell line through the modulation of autophagic fluxDOI 10.1016/j.crbiot.2020.05.001Read

Fighting Carcinogenesis with Plant Metabolites by Weakening Proliferative Signaling and Disabling Replicative Immortality Networks of Rapidly Dividing and Invading Cancerous CellsSemantic proximity Read

The Antitumour Mechanisms of Carotenoids: A Comprehensive ReviewSemantic proximity Read

Carotenoids and Carcinogenesis: Exploring the Antioxidant and Cell Signaling Roles of Carotenoids in the Prevention of CancerSemantic proximity Read

Carotenoid-Enriched Nanoemulsions and γ-Rays Synergistically Induce Cell Death in a Novel Radioresistant Osteosarcoma Cell LineSemantic proximity Read

Plant natural compounds: targeting pathways of autophagy as anti‐cancer therapeutic agentsSemantic proximity Read

Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma CellsSemantic proximity Read

The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells.Semantic proximity Read

The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin PatentsSemantic proximity Read

Catharanthine, an anticancer vinca alkaloid: an in silico and in vitro analysis of the autophagic system as the major mechanism of cell death in liver HepG2 cellsSemantic proximity Read

Eupafolin induces autophagy and apoptosis in B-cell non-Hodgkin lymphomasSemantic proximity Read

Overview of Mechanisms of Action of LycopeneSemantic proximity Read

Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for CancerSemantic proximity Read