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Article

p53 represses autophagy in a cell cycle-dependent fashion

1 Oct 2008

Abstract excerpt

Autophagy is one of the principal mechanisms of cellular defense against nutrient depletion and damage to cytoplasmic organelles. When p53 is inhibited by a pharmacological antagonist (cyclic pifithrin-alpha), depleted by a specific small interfering RNA (siRNA) or deleted by homologous recombination, multiple signs of autophagy are induced. Here, we show by epistatic analysis that p53 inhibition results in a...

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PMID: 18838865
DOI: 10.4161/cc.7.19.6702

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