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Article

Role of Beclin-1-Mediated Autophagy in the Survival of Pediatric Leukemia Cells

1 Jan 2016

Abstract excerpt

BACKGROUND/AIMS: Acute and chronic leukemia are severe malignant cancers worldwide, and can occur in pediatric patients. Since bone marrow cell transplantation is seriously limited by the availability of the immune-paired donor sources, the therapy for pediatric leukemia (PL) remains challenging. Autophagy is essential for the regulation of cell survival in the harsh environment. However, the role of autophagy in...

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PMID: 27744427
DOI: 10.1159/000447882

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