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Article

Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy‐mediated differentiation

13 Sept 2017

Abstract excerpt

BACKGROUND AND PURPOSE: The poor prognosis of acute megakaryoblastic leukaemia (AMKL) means there is a need to develop novel therapeutic methods to treat this condition. It was recently shown that inducing megakaryoblasts to undergo terminal differentiation is effective as a treatment for AMKL. This encouraged us to identify a compound that induces megakaryocyte differentiation, which could then act as a potent...

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PMID: 28901537
DOI: 10.1111/bph.14031

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