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Article

cFos mediates cAMP-dependent generation of ROS and rescue of maturation program in retinoid-resistant acute promyelocytic leukemia cell line NB4-LR1.

PloS one - 1 Jan 2012

Carrier Jean-Luc, Javadi Pasha, Bourrier Emilie, Camus Céline, Ségal-Bendirdjian Evelyne, Karniguian Aïda

Abstract excerpt

A determining role has been assigned to cAMP in the signaling pathways that relieve resistance to anti-leukemia differentiation therapy. However, the underlying mechanisms have not been elucidated yet. Here, we identify cFos as a critical cAMP effector, able to regulate the re-expression and splicing of epigenetically silenced genes associated with maturation (CD44) in retinoid-resistant NB4-LR1 leukemia cells....

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Identifiers

PMID: 23209736
DOI: 10.1371/journal.pone.0050408
PMCID: PMC3508928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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