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Article

Statin treatment reduces matrix degradation capacity of proinflammatory polarized macrophages.

Vascular pharmacology - 1 Nov 2018

Hohensinner P J, Baumgartner J, Ebenbauer B, Thaler B, Fischer M B, Huber K, Speidl W S, Wojta J

Abstract excerpt

BACKGROUND AND AIMS: Macrophages are versatile immune cells involved in tissue degradation and remodeling. Proinflammatory macrophages have the highest capacity of matrix degradation and proteolysis. Within atherosclerotic lesions, proinflammatory macrophages are associated with unstable plaques. Statins have been demonstrated to increase plaque stability. Possible changes of polarized macrophage tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30098417
DOI: 10.1016/j.vph.2018.08.003

Genes

MMP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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