Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The lysosomal transfer of LDL/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration.

Cardiovascular research - 1 Mar 2013

Weinert Sönke, Poitz David M, Auffermann-Gretzinger Susanne, Eger Lars, Herold Joerg, Medunjanin Senad, Schmeisser Alexander, Strasser Ruth H, Braun-Dullaeus Ruediger C

Abstract excerpt

AIMS: Macrophages (MPs) and vascular smooth muscle cells (VSMCs) closely interact within the growing atherosclerotic plaque. An in vitro co-culture model was established to study how MPs modulate VSMC behaviour. METHODS AND RESULTS: MPs were exposed to fluorescence-labelled-acetylated LDL (FL-acLDL) prior to co-culture with VSMCs. Fluorescence microscopy visualized first transport of FL-acLDL within 6 h after...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta, Abdominal
Share to Cell Communication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Hydroxymethylglutaryl CoA Reductases

Share to Lipoproteins, LDL

Share to Lysosomal-Associated Membrane Protein 1

Share to Lysosomes

Share to Rats, Wistar

Source

Identifiers

PMID: 23250921
DOI: 10.1093/cvr/cvs367

Genes

LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lysosomal transfer of LDL/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration.PMID 23250921Read ↗

Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque responsesSemantic proximity Read ↗

Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading.Semantic proximity Read ↗

Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.Semantic proximity Read ↗

Extracellular vesicles from chylomicron-treated endothelial cells drive macrophage inflammationSemantic proximity Read ↗

Role of Rab5 in the formation of macrophage-derived foam cell.Semantic proximity Read ↗

The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation.Semantic proximity Read ↗

Protocol for oil red O staining of low-density lipoproteins for in vivo cell treatmentSemantic proximity Read ↗

Very-low and low-density lipoproteins induce neutral lipid accumulation and impair migration in monocyte subsets.Semantic proximity Read ↗

Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking.Semantic proximity Read ↗

Statin treatment reduces matrix degradation capacity of proinflammatory polarized macrophages.Semantic proximity Read ↗

[Role of monocytes-macrophages in atherogenesis].Semantic proximity Read ↗

Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.