Article
Expression pattern analysis and activity determination of matrix metalloproteinase derived from human macrophage subsets.
Clinical hemorheology and microcirculation - 1 Jan 2014
Roch Toralf, Akymenko Oksana, Krüger Anne, Jung Friedrich, Ma Nan, Lendlein Andreas
Abstract excerpt
The polarization behavior of macrophages determines the clinical outcome after implantation of biomaterials. Formation of classically activated macrophages (CAM) may result in cell fusion to form foreign body giant cells, which induce and support uncontrolled inflammatory responses and can cause undesired material degradation. In contrast, polarization into alternatively activated macrophages (AAM) is assumed to...
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