Article
Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia.
The Journal of molecular diagnostics : JMD - 1 Sept 2017
Benard-Slagter Anne, Zondervan Ilse, de Groot Karel, Ghazavi Farzaneh, Sarhadi Virinder, Van Vlierberghe Pieter, De Moerloose Barbara, Schwab Claire, Vettenranta Kim, Harrison Christine J, Knuutila Sakari, Schouten Jan, Lammens Tim, Savola Suvi
Abstract excerpt
Recurrent and clonal genetic alterations are characteristic of different subtypes of T- and B-cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors of clinical outcome. A next-generation sequencing-based multiplex ligation-dependent probe amplification variant (digitalMLPA) has been developed enabling simultaneous detection of copy number alterations (CNAs) of up to 1000 target...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.