Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Respiratory Manifestations of the Activated Phosphoinositide 3-Kinase Delta Syndrome.

Frontiers in immunology - 1 Jan 2018

Condliffe Alison M, Chandra Anita

Abstract excerpt

The activated phosphoinositide 3-kinase δ syndrome (APDS), also known as p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI), is a combined immunodeficiency syndrome caused by gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (encoding p110δ: APDS1 or PASLI-CD) and PIK3R1 (encoding p85α: APDS2 or PASLI-R1). While the disease is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allografts
Share to Class Ia Phosphatidylinositol 3-Kinase
Share to Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoproliferative Disorders

Share to Primary Immunodeficiency Diseases

Share to Respiratory Tract Infections

Share to Sirolimus

Share to Stem Cell Transplantation

Source

Open in PubMed Open full text

Identifiers

PMID: 29556229
DOI: 10.3389/fimmu.2018.00338
PMCID: PMC5844940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Respiratory Manifestations of the Activated Phosphoinositide 3-Kinase Delta Syndrome.PMID 29556229Read ↗

Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta SyndromesSemantic proximity Read ↗

Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study.Semantic proximity Read ↗

Activated PI3Kinase Delta Syndrome—A Multifaceted DiseaseSemantic proximity Read ↗

Infections in activated PI3K delta syndrome (APDS).Semantic proximity Read ↗

Clinical Manifestations and Outcomes of Activated Phosphoinositide 3-Kinase δ Syndrome from the USIDNET Cohort.Semantic proximity Read ↗

PI3Kδ and primary immunodeficiencies.Semantic proximity Read ↗

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.Semantic proximity Read ↗

An updated review on activated PI3 kinase delta syndrome (APDS)Semantic proximity Read ↗

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.Semantic proximity Read ↗

The First Iranian Cohort of Pediatric Patients with Activated Phosphoinositide 3-Kinase-δ (PI3Kδ) Syndrome (APDS).Semantic proximity Read ↗

Report of the Italian Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome in the Target Therapy Era.Semantic proximity Read ↗

Activated phosphoinositide 3-dinase delta syndrome (APDS): An update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.