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An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.

Cell host & microbe - 8 Aug 2018

Wang Liuyang, Pittman Kelly J, Barker Jeffrey R, Salinas Raul E, Stanaway Ian B, Williams Graham D, Carroll Robert J, Balmat Tom, Ingham Andy, Gopalakrishnan Anusha M, Gibbs Kyle D, Antonia Alejandro L, Heitman Joseph, Lee Soo Chan, Jarvik Gail P, Denny Joshua C, Horner Stacy M, DeLong Mark R, Valdivia Raphael H, Crosslin David R, Ko Dennis C

Abstract excerpt

Pathogens have been a strong driving force for natural selection. Therefore, understanding how human genetic differences impact infection-related cellular traits can mechanistically link genetic variation to disease susceptibility. Here we report the Hi-HOST Phenome Project (H2P2): a catalog of cellular genome-wide association studies (GWAS) comprising 79 infection-related phenotypes in response to 8 pathogens in...

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Identifiers

PMID: 30092202
DOI: 10.1016/j.chom.2018.07.007
PMCID: PMC6093297

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CXCL10
ZBTB20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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