Article
The genetic architecture of human infectious diseases and pathogen-induced cellular phenotypes
2020-07-21
Abstract excerpt
Here, we develop a genetics-anchored framework to decipher mechanisms of infectious disease (ID) risk and infer causal effect on potential complications. We perform transcriptome-wide association studies (TWAS) of 35 ID traits in 27,615 individuals in a broad collection of human tissues, identifying 70 gene-level associations with 26 ID traits, with replication in two large-scale biobanks. A phenome-scale scan and...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 00c6c94c-52a7-58a7-b0b8-9e6c6fd14953
- DOI
- 10.1101/2020.07.19.20157404