Article

Causal genetics prioritizes therapeutic targets and blood signatures in primary biliary cholangitis

2026-08-21

Abstract excerpt

Primary biliary cholangitis is an autoimmune cholestatic liver disease, but upstream immune programs linking inherited risk to hepatic remodeling and therapeutic targets remain incompletely defined. We developed a cross-tissue causal multi-omics framework integrating PBC GWAS, 731 GWAS-derived immune traits, peripheral blood transcriptomes, and liver bulk and single-cell RNA-seq. Two-sample Mendelian randomization...

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Literature Corpus work: 93d453ba-bbce-5edb-94a4-9ba2b7c959bc
DOI: 10.1038/s41540-026-00817-w

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