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Article

Investigating the genetic architecture of general and specific psychopathology in adolescence.

Translational psychiatry - 8 Aug 2018

Jones Hannah J, Heron Jon, Hammerton Gemma, Stochl Jan, Jones Peter B, Cannon Mary, Smith George Davey, Holmans Peter, Lewis Glyn, Linden David E J, O'Donovan Michael C, Owen Michael J, Walters James, Zammit Stanley

Abstract excerpt

Whilst associations between polygenic risk scores (PRSs) for schizophrenia and various phenotypic outcomes have been reported, an understanding of developmental pathways can only be gained by modelling comorbidity across psychopathology. We examine how genetic risk for schizophrenia relates to adolescent psychosis-related and internalizing psychopathology using a latent modelling approach, and compare this to...

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Identifiers

PMID: 30089819
DOI: 10.1038/s41398-018-0204-9
PMCID: PMC6082910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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