Article
Requirement for MUC5AC in KRAS-dependent lung carcinogenesis.
JCI insight - 9 Aug 2018
Bauer Alison K, Umer Misha, Richardson Vanessa L, Cumpian Amber M, Harder Anna Q, Khosravi Nasim, Azzegagh Zoulikha, Hara Naoko M, Ehre Camille, Mohebnasab Maedeh, Caetano Mauricio S, Merrick Daniel T, van Bokhoven Adrie, Wistuba Ignacio I, Kadara Humam, Dickey Burton F, Velmurugan Kalpana, Mann Patrick R, Lu Xian, Barón Anna E, Evans Christopher M, Moghaddam Seyed Javad
Abstract excerpt
With more than 150,000 deaths per year in the US alone, lung cancer has the highest number of deaths for any cancer. These poor outcomes reflect a lack of treatment for the most common form of lung cancer, non-small cell lung carcinoma (NSCLC). Lung adenocarcinoma (ADC) is the most prevalent subtype of NSCLC, with the main oncogenic drivers being KRAS and epidermal growth factor receptor (EGFR). Whereas EGFR...
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