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Article

KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2013

Rekhtman Natasha, Ang Daphne C, Riely Gregory J, Ladanyi Marc, Moreira Andre L

Abstract excerpt

KRAS mutations define a clinically distinct subgroup of lung adenocarcinoma patients, characterized by smoking history, resistance to EGFR-targeted therapies, and adverse prognosis. Whether KRAS-mutated lung adenocarcinomas also have distinct histopathological features is not well established. We tested 180 resected lung adenocarcinomas for KRAS and EGFR mutations by high-sensitivity mass spectrometry-based...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
ErbB Receptors
Female
Humans
Leukocytes
Lung Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Invasiveness

Proto-Oncogene Proteins

Proto-Oncogene Proteins p21(ras)

ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23619604
DOI: 10.1038/modpathol.2013.74
PMCID: PMC3732528

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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