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Article

Activating KRAS mutations mark premalignant cystic structures in congenital pulmonary airway malformations.

Respiratory research - 15 Jan 2026

van Horik Cathy, Benthem Floor, Buscop-van Kempen Marjon, Boerema-de Munck Anne, van IJcken Wilfred F J, Wijnen Rene M H, Schnater Marco, Rottier Robbert J

Abstract excerpt

BACKGROUND: Congenital Pulmonary Airway malformations (CPAM) may lead to malignant degeneration, and therefore many surgeons opt to resect CPAM even in asymptomatic patients. Previously, we identified Kirsten rat sarcoma virus (KRAS) mutations in a subset of CPAM patients, possibly indicating a pre-malignant state. In order to unify treatment strategy in (asymptomatic) patients we focused on KRAS mutations as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41540433
DOI: 10.1186/s12931-025-03491-4
PMCID: PMC12892516

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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