Genetic and epigenetic changes in lung carcinoma and their clinical implications.

doi:10.1038/modpathol.2011.46

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Article

Genetic and epigenetic changes in lung carcinoma and their clinical implications.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2011

Wen Jing, Fu Jianhua, Zhang Wei, Guo Ming

Abstract excerpt

Lung cancer is the leading cause of cancer deaths worldwide. Recent advance in targeted therapy for lung cancer patients with epidermal growth factor receptor (EGFR) mutations has demonstrated a promising development toward personalized therapy for lung cancer patients. The development of lung cancer is a complex process, involving a series of genetic and epigenetic changes. Tobacco smoke is the predominant...

Topics

Carcinoma
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Loss of Heterozygosity
Lung Neoplasms
Mutation

Source

Open in PubMed

Identifiers

PMID: 21423157
DOI: 10.1038/modpathol.2011.46

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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