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Article

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus.

PloS one - 1 Jan 2018

Laban Sandra, Suwandi Jessica S, van Unen Vincent, Pool Jos, Wesselius Joris, Höllt Thomas, Pezzotti Nicola, Vilanova Anna, Lelieveldt Boudewijn P F, Roep Bart O

Abstract excerpt

Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen- (pre-proinsulin), neoantigen- (insulin-DRIP) and virus- (cytomegalovirus) reactive CD8 T-cells in peripheral blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

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Source

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Identifiers

PMID: 30089176
DOI: 10.1371/journal.pone.0200818
PMCID: PMC6082515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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