Article

Ventricular, atrial and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak

2020-07-12

Abstract excerpt

The heart develops from two sources of mesoderm progenitors, the first and second heart field (FHF and SHF). Using a single cell transcriptomic assay in combination with genetic lineage tracing, we find the FHF and SHF are subdivided into distinct pools of progenitors in gastrulating mouse embryos at earlier stages than previously thought. Each subpopulation has a distinct origin in the primitive streak. The first...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c91aac1-0d06-5d39-b8c1-baeb28a843de
DOI: 10.1101/2020.07.12.198994

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ventricular, atrial and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streakDOI 10.1101/2020.07.12.198994Read

Unveiling unexpected complexity and multipotentiality of early heart fieldsSemantic proximity Read

A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivativesSemantic proximity Read

A molecular and genetic outline of cardiac morphogenesisSemantic proximity Read

Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart fieldSemantic proximity Read

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potentialSemantic proximity Read

Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesisSemantic proximity Read

The formation of the embryonic mouse heartSemantic proximity Read

Organogenesis of the vertebrate heartSemantic proximity Read

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.Semantic proximity Read

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and DiseaseSemantic proximity Read

Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineageSemantic proximity Read

Early patterning and specification of cardiac progenitors in gastrulating mesodermSemantic proximity Read