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Article

Structural determinant of functionality in acyl lipid desaturases.

Journal of lipid research - 1 Oct 2018

Sastre Diego E, Saita Emilio, Uttaro Antonio D, de Mendoza Diego, Altabe Silvia G

Abstract excerpt

Little is known about the structure-function relationship of membrane-bound lipid desaturases. Using a domain-swapping strategy, we found that the N terminus (comprising the two first transmembrane segments) region of Bacillus cereus DesA desaturase improves Bacillus subtilis Des activity. In addition, the replacement of the first two transmembrane domains from Bacillus licheniformis inactive open reading frame...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30087203
DOI: 10.1194/jlr.M085258
PMCID: PMC6168307

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