Article
Structural control of chemoselectivity, stereoselectivity, and substrate specificity in membrane-bound fatty acid acetylenases and desaturases.
Biochemistry - 29 Dec 2009
Gagné Steve J, Reed Darwin W, Gray Gordon R, Covello Patrick S
Abstract excerpt
The FAD2-like desaturases comprise a group of membrane-bound oxygenases involved in the modification of fatty acyl groups in plants and fungi. This group includes typical oleate desaturases which introduce a Delta12 cis double bond and more unusual enzymes such as Crep1, an acetylenase from the plant Crepis alpina, which introduces a triple bond in linoleate at the Delta12 position. In this study, the...
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