Article
The flexible C-terminal region of Aspergillus terreus blasticidin S deaminase: identification of its functional roles with deletion enzymes.
Biochemical and biophysical research communications - 11 Jan 2002
Kimura Makoto, Furuichi Makio, Yamamoto Masaki, Kumasaka Takashi, Mizuno Hiroshi, Miyano Masashi, Yamaguchi Isamu
Abstract excerpt
Although the four polypeptides of blasticidin S (BS) deaminase (BSD) are packed rather tightly coordinated to the "structural and catalytic" zinc atom of each subunit, the C-terminal region of the enzyme was suggested to be somewhat molten and flexible [M. Kimura, S. Sekido, Y. Isogai, and I. Yamaguchi (2000) J. Biochem. 127, 955-963]. To understand roles of this flexible region, we constructed five C-terminal...
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