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Article

A single mutation in the castor Delta9-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry.

Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006

Guy Jodie E, Abreu Isabel A, Moche Martin, Lindqvist Ylva, Whittle Edward, Shanklin John

Abstract excerpt

Sequence analysis of the diiron cluster-containing soluble desaturases suggests they are unrelated to other diiron enzymes; however, structural alignment of the core four-helix bundle of desaturases to other diiron enzymes reveals a conserved iron binding motif with similar spacing in all enzymes of this structural class, implying a common evolutionary ancestry. Detailed structural comparison of the castor...

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PMID: 17088542
DOI: 10.1073/pnas.0607165103
PMCID: PMC1859913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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