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Article

A Transmembrane Histidine Kinase Functions as a pH Sensor.

Biomolecules - 14 Aug 2020

Bortolotti Ana, Vazquez Daniela Belén, Almada Juan Cruz, Inda Maria Eugenia, Drusin Salvador Iván, Villalba Juan Manuel, Moreno Diego M, Ruysschaert Jean Marie, Cybulski Larisa Estefania

Abstract excerpt

The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations. Here, we found that DesK-the transmembrane histidine kinase-also responds to pH and studied the mechanism of pH sensing. We propose that a helix linking the transmembrane region...

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Identifiers

PMID: 32823946
DOI: 10.3390/biom10081183
PMCID: PMC7465017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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