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Article

The structural roles of a conserved small hydrophobic core in the active site and an ionic bridge in domain I of Delta class glutathione S-transferase.

The Biochemical journal - 1 Jan 2006

Vararattanavech Ardcharaporn, Prommeenate Peerada, Ketterman Albert J

Abstract excerpt

GSTs (glutathione S-transferases; E.C.2.5.1.18) are a supergene family of dimeric multifunctional enzymes that have a major role in detoxification pathways. Using a GST from the mosquito Anopheles dirus (adGSTD4-4), we have characterized the enzymatic and physical properties of Leu-6, Thr-31, Leu-33, Ala-35, Glu-37, Lys-40 and Glu-42. These residues generate two motifs located in the N-terminal domain (domain I)...

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Identifiers

PMID: 16153184
DOI: 10.1042/BJ20050555
PMCID: PMC1383667

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Source receipt: pubmed, retrieved 7 Sept 2026.

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