Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PCBP-1 Regulates the Transcription and Alternative Splicing of Inflammation and Ubiquitination-Related Genes in PC12 Cell

20 Jun 2022

Abstract excerpt

PCBP-1, a multifunctional RNA binding protein, is expressed in various human cell/tissue types and involved in post-transcriptional gene regulation. PCBP-1 has important roles in cellular Iron homeostasis, mitochondrial stability, and other cellular activities involved in the pathophysiological process of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Prion Diseases and Protein Misfolding
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35795237
DOI: 10.3389/fnagi.2022.884837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PCBP-1 Regulates the Transcription and Alternative Splicing of Inflammation and Ubiquitination-Related Genes in PC12 CellPMID 35795237Read ↗

PCBP1 overexpression protects dopaminergic neurons in a model of Parkinson's diseaseSemantic proximity Read ↗

CDIP1 as a novel therapeutic target in rheumatoid arthritis: WGCNA and machine learning-driven discovery of ubiquitination-mediated immune and apoptotic dysregulationSemantic proximity Read ↗

Distinct roles of IDR and CCD domains control PABPN1 aggregation and enable therapeutic rescueSemantic proximity Read ↗

DE NOVO VARIANTS IN THE POLY(RC)-BINDING PROTEIN GENE <i>PCBP1</i> CAUSE A NEURODEVELOPMENTAL DISORDERSemantic proximity Read ↗

BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseasesSemantic proximity Read ↗

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping.Semantic proximity Read ↗

PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translationSemantic proximity Read ↗

N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processingSemantic proximity Read ↗

Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex developmentSemantic proximity Read ↗

Overexpression of PCBP2 contributes to poor prognosis and enhanced cell growth in human hepatocellular carcinomaSemantic proximity Read ↗

EEF1A1 knock-down regulates the expression and alternative splicing of genes associated with Parkinson`s disease in U251 cellsSemantic proximity Read ↗

Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.