Article

Blending physics-based and inverse folding models to disentangle variant effects on stability and function

2026-08-04

Abstract excerpt

Protein sequences are constrained not only by the need to fold into stable structures, but also by specific functional requirements imposed by natural selection. Yet predictions of how amino-acid changes affect proteins typically collapse these constraints into a single scalar score. Quantitatively separating these effects at scale remains an open challenge, with direct relevance spanning protein design to underst...

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Literature Corpus work: d674211c-6196-5c13-9ed2-ece247c60108
DOI: 10.64898/2026.07.30.741764

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