Article
Searching for a mechanistic description of pairwise epistasis in protein systems.
Proteins - 1 Jul 2022
Barnes Jonathan E, Miller Craig R, Ytreberg Frederick Marty
Abstract excerpt
When two or more amino acid mutations occur in protein systems, they can interact in a nonadditive fashion termed epistasis. One way to quantify epistasis between mutation pairs in protein systems is by using free energy differences: ϵ = ΔΔG1,2 - (ΔΔG1 + ΔΔG2 ) where ΔΔG refers to the change in the Gibbs free energy, subscripts 1 and 2 refer to single mutations in arbitrary order and 1,2 refers to the double...
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