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Article

Inhibition of H3K27me3 demethylases attenuates asthma by reversing the shift in airway smooth muscle phenotype.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2018

Yu Qijun, Yu Xiaowei, Zhao Wenxue, Zhu Manni, Wang Zhengxia, Zhang Jiaxiang, Huang Mao, Zeng Xiaoning

Abstract excerpt

BACKGROUND: The shift in airway smooth muscle cells (ASMCs) phenotype between proliferation and contraction during asthma has been reported recently, highlighting a role of ASMCs plasticity in the pathophysiology of asthma. As an event involved in epigenetic post-translational modification, histone H3 lysine27 (H3K27) demethylation has attracted significant attention with respect to the epigenetic changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30084510
DOI: 10.1111/cea.13244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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