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Article

Fisetin reduces ovalbumin-triggered airway remodeling by preventing phenotypic switching of airway smooth muscle cells.

Respiratory research - 14 Oct 2024

Liu Yuanyuan, Yin Qiling, Liu Bin, Lu Zheng, Liu Meijun, Meng Ling, He Chao, Chang Jin

Abstract excerpt

BACKGROUND: The transformation of airway smooth muscle cells (ASMCs) from a quiescent phenotype to a hypersecretory and hypercontractile phenotype is a defining feature of asthmatic airway remodeling. Fisetin, a flavonoid compound, possesses anti-inflammatory characteristics in asthma; yet, its impact on airway remodeling and ASMCs phenotype transition has not been investigated. OBJECTIVES: This research seeked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39402516
DOI: 10.1186/s12931-024-03005-8
PMCID: PMC11479573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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