Article
Genome-wide identification of directed gene networks using large-scale population genomics data.
Nature communications - 6 Aug 2018
Luijk René, Dekkers Koen F, van Iterson Maarten, Arindrarto Wibowo, Claringbould Annique, Hop Paul, Boomsma Dorret I, van Duijn Cornelia M, van Greevenbroek Marleen M J, Veldink Jan H, Wijmenga Cisca, Franke Lude, 't Hoen Peter A C, Jansen Rick, van Meurs Joyce, Mei Hailiang, Slagboom P Eline, Heijmans Bastiaan T, van Zwet Erik W
Abstract excerpt
Identification of causal drivers behind regulatory gene networks is crucial in understanding gene function. Here, we develop a method for the large-scale inference of gene-gene interactions in observational population genomics data that are both directed (using local genetic instruments as causal anchors, akin to Mendelian Randomization) and specific (by controlling for linkage disequilibrium and pleiotropy)....
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