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Article

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.

Nature communications - 6 Aug 2018

Ludlow Andrew T, Wong Mandy Sze, Robin Jerome D, Batten Kimberly, Yuan Laura, Lai Tsung-Po, Dahlson Nicole, Zhang Lu, Mender Ilgen, Tedone Enzo, Sayed Mohammed E, Wright Woodring E, Shay Jerry W

Abstract excerpt

Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing factors that enhance or silence FL hTERT is lacking. We identified splicing factors that reduced telomerase activity and shortened telomeres using a siRNA minigene reporter screen and a lung cancer cell bioinformatics approach. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30082712
DOI: 10.1038/s41467-018-05582-x
PMCID: PMC6079032

Genes

NOVA1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.PMID 30082712Read ↗

Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death.Semantic proximity Read ↗

Epigenetic–splicing regulation of <i>hTERT</i> mediated by <i>hTAPAS</i>Semantic proximity Read ↗

TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERTSemantic proximity Read ↗

hTERT promotes cell adhesion and migration independent of telomerase activity.Semantic proximity Read ↗

The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase ActivitySemantic proximity Read ↗

Alternative splicing is a developmental switch for hTERT expressionSemantic proximity Read ↗

Real-Time RT-PCR Quantification of Human Telomerase Reverse Transcriptase Splice Variants in Tumor Cell Lines and Non–Small Cell Lung CancerSemantic proximity Read ↗

The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from ApoptosisSemantic proximity Read ↗

Regulation of Telomerase Activity by Alternate Splicing of Human Telomerase Reverse Transcriptase mRNA in a Subset of NeuroblastomasSemantic proximity Read ↗

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues.Semantic proximity Read ↗

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.Semantic proximity Read ↗

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