Article

Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death.

2024-11-18

Abstract excerpt

<title>Abstract</title> <p>All cancer cells must adopt a telomere maintenance mechanism to achieve replicative immortality. Most human cancer cells utilize the enzyme telomerase to maintain telomeres. Alternative splicing of TERT regulates the amount and function of telomerase, however many alternative splicing isoforms of TERT have unknown functions. Single molecule long read RNA/cDNA sequencing of TERT revealed...

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Literature Corpus work: 3e8c20f0-58bd-51bd-8ddb-617c8bb6b71a
DOI: 10.21203/rs.3.rs-5305451/v1

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