Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.

Molecular and cellular biology - 1 Nov 2012

Hrdlicková Radmila, Nehyba Jirí, Bose Henry R

Abstract excerpt

Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in-frame deletion which removed exons 4 through 13, encoding the catalytic domain of telomerase. This variant was expre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Chickens
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA Interference

Share to RNA, Small Interfering

Share to Telomerase

Share to Telomere

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 22907755
DOI: 10.1128/MCB.00550-12
PMCID: PMC3486134

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22907755-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.PMID 22907755Read ↗

Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity.Semantic proximity Read ↗

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase ActivitySemantic proximity Read ↗

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological ProcessesSemantic proximity Read ↗

Exclusion of Exon 2 Is a Common mRNA Splice Variant of Primate Telomerase Reverse TranscriptasesSemantic proximity Read ↗

Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo.Semantic proximity Read ↗

Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometriumSemantic proximity Read ↗

[Telomerase antagonists].Semantic proximity Read ↗

Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human developmentSemantic proximity Read ↗

Cancer-associated TERT promoter mutations abrogate telomerase silencing.Semantic proximity Read ↗

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potentialSemantic proximity Read ↗

Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death.Semantic proximity Read ↗

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.