Article
Genotype-targeted local therapy of glioma.
Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2018
Shankar Ganesh M, Kirtane Ameya R, Miller Julie J, Mazdiyasni Hormoz, Rogner Jaimie, Tai Tammy, Williams Erik A, Higuchi Fumi, Juratli Tareq A, Tateishi Kensuke, Koerner Mara V A, Tummala Shilpa S, Fink Alexandria L, Penson Tristan, Schmidt Stephen P, Wojtkiewicz Gregory R, Baig Aymen, Francis Joshua M, Rinne Mikael L, Batten Julie M, Batchelor Tracy T, Brastianos Priscilla K, Curry William T, Barker Fred G, Jordan Justin T, Iafrate A John, Chi Andrew S, Lennerz Jochen K, Meyerson Matthew, Langer Robert, Wakimoto Hiroaki, Traverso Giovanni, Cahill Daniel P
Abstract excerpt
Aggressive neurosurgical resection to achieve sustained local control is essential for prolonging survival in patients with lower-grade glioma. However, progression in many of these patients is characterized by local regrowth. Most lower-grade gliomas harbor isocitrate dehydrogenase 1 (IDH1) or IDH2 mutations, which sensitize to metabolism-altering agents. To improve local control of IDH mutant gliomas while...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.