Article
Advances in Treatment of Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastomas.
Current neurology and neuroscience reports - 1 Jun 2023
Sim Hao-Wen, Lorrey Selena, Khasraw Mustafa
Abstract excerpt
PURPOSE OF REVIEW: The management of isocitrate dehydrogenase (IDH)-wildtype glioblastomas is an area of unmet need. Despite multimodal therapy incorporating maximal safe resection, radiotherapy, and temozolomide, clinical outcomes remain poor. At disease progression or relapse, available systemic agents such as temozolomide, lomustine, and bevacizumab have limited efficacy. We review the recent advances in the...
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