Article
Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae.
Microbial genomics - 1 Sept 2018
Cleary David W, Devine Vanessa T, Morris Denise E, Osman Karen L, Gladstone Rebecca A, Bentley Stephen D, Faust Saul N, Clarke Stuart C
Abstract excerpt
The implementation of pneumococcal conjugate vaccines (PCVs) has led to a decline in vaccine-type disease. However, there is evidence that the epidemiology of non-typeable Haemophilus influenzae (NTHi) carriage and disease can be altered as a consequence of PCV introduction. We explored the epidemiological shifts in NTHi carriage using whole genome sequencing over a 5-year period that included PCV13 replacement...
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