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Article

Clonal expansion within pneumococcal serotype 6C after use of seven-valent vaccine.

PloS one - 1 Jan 2013

Loman Nicholas J, Gladstone Rebecca A, Constantinidou Chrystala, Tocheva Anna S, Jefferies Johanna M C, Faust Saul N, O'Connor Leigh, Chan Jacqueline, Pallen Mark J, Clarke Stuart C

Abstract excerpt

Streptococcus pneumoniae causes invasive infections, primarily at the extremes of life. A seven-valent conjugate vaccine (PCV7) is used to protect against invasive pneumococcal disease in children. Within three years of PCV7 introduction, we observed a fourfold increase in serotype 6C carriage, predominantly due to a single clone. We determined the whole-genome sequences of nineteen S. pneumoniae serotype 6C...

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Identifiers

PMID: 23724086
DOI: 10.1371/journal.pone.0064731
PMCID: PMC3665553

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Source receipt: pubmed, retrieved 7 Sept 2026.

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