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Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer

26 Jul 2019

Abstract excerpt

BACKGROUND: To profile genomic and epigenomic of a naïve Chinese non-small cell lung cancer (NSCLC) cohort and investigate the association between tumor mutation burden (TMB) and DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. METHODS: A total of 89 tumor tissues with matched normal tissues from Chinese NSCLC patients were collected and subjected to...

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PMID: 31349879
DOI: 10.1186/s40425-019-0660-7

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