Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.

doi:10.1038/ng.2639

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Article

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.

Nature genetics - 1 Jun 2013

Kou Ikuyo, Takahashi Yohei, Johnson Todd A, Takahashi Atsushi, Guo Long, Dai Jin, Qiu Xusheng, Sharma Swarkar, Takimoto Aki, Ogura Yoji, Jiang Hua, Yan Huang, Kono Katsuki, Kawakami Noriaki, Uno Koki, Ito Manabu, Minami Shohei, Yanagida Haruhisa, Taneichi Hiroshi, Hosono Naoya, Tsuji Taichi, Suzuki Teppei, Sudo Hideki, Kotani Toshiaki, Yonezawa Ikuho, Londono Douglas, Gordon Derek, Herring John A, Watanabe Kota, Chiba Kazuhiro, Kamatani Naoyuki, Jiang Qing, Hiraki Yuji, Kubo Michiaki, Toyama Yoshiaki, Tsunoda Tatsuhiko, Wise Carol A, Qiu Yong, Shukunami Chisa, Matsumoto Morio, Ikegawa Shiro

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We previously reported a locus on chromosome 10q24.31 associated with AIS susceptibility in Japanese using a genome-wide association study (GWAS) consisting of 1,033 cases and 1,473 controls. To identify additional AIS-associated loci, we expanded the study by adding X-chromosome SNPs in the GWAS and increasing the size of the...

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PMID: 23666238
DOI: 10.1038/ng.2639

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