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Epigenetic immune cell counting in human blood samples for immunodiagnostics

1 Aug 2018

Abstract excerpt

regulatory T cells was evaluated, demonstrating substantial equivalence between epigenetic qPCR analysis and flow cytometry. Epigenetic qPCR achieves both relative and absolute quantifications. Applied to dried blood spots, epigenetic immune cell quantification was shown to identify newborns suffering from various primary immunodeficiencies. Using epigenetic qPCR not only provides a precise means for immune cell...

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PMID: 30068569
DOI: 10.1126/scitranslmed.aan3508

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