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Article

Cellular signatures of immune dysregulation in inborn errors of immunity: development of a quantitative immune balance score.

Frontiers in immunology - 1 Jan 2026

Inan Dilan, Bildik Hacer Neslihan, Ciftcier Busra, Akarsu Aysegul, Ocak Melike, Bolat Aslihan Berra, Cagdas Deniz, Tezcan Ilhan, Halacli Sevil Oskay

Abstract excerpt

Background: Immune dysregulation, classified as distinct phenotypes within inborn errors of immunity (IEIs) and collectively known as primary immune regulatory disorders (PIRD) is increasingly recognized as a major contributor to morbidity; however, the quantitative cellular signatures identifying this state remain incompletely characterized. Objective: We aimed to describe cellular changes underlying immune...

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Identifiers

PMID: 41869351
DOI: 10.3389/fimmu.2026.1735655
PMCID: PMC12999435

Genes

IDS
BCL6
CD4
FOXP3
ICOS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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