Article
Emerging ensembles of kinetic parameters to characterize observed metabolic phenotypes.
BMC bioinformatics - 9 Jul 2018
Colombo Riccardo, Damiani Chiara, Gilbert David, Heiner Monika, Mauri Giancarlo, Pescini Dario
Abstract excerpt
BACKGROUND: Determining the value of kinetic constants for a metabolic system in the exact physiological conditions is an extremely hard task. However, this kind of information is of pivotal relevance to effectively simulate a biological phenomenon as complex as metabolism. RESULTS: To overcome this issue, we propose to investigate emerging properties of ensembles of sets of kinetic constants leading to the...
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