Article
Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes.
Current opinion in biotechnology - 1 Dec 2015
Miskovic Ljubisa, Tokic Milenko, Fengos Georgios, Hatzimanikatis Vassily
Abstract excerpt
The overarching ambition of kinetic metabolic modeling is to capture the dynamic behavior of metabolism to such an extent that systems and synthetic biology strategies can reliably be tested in silico. The lack of kinetic data hampers the development of kinetic models, and most of the current models use ad hoc reduced stoichiometry or oversimplified kinetic rate expressions, which may limit their predictive...
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