Article
A kinetic model of Escherichia coli core metabolism satisfying multiple sets of mutant flux data.
Metabolic engineering - 1 Sept 2014
Khodayari Ali, Zomorrodi Ali R, Liao James C, Maranas Costas D
Abstract excerpt
In contrast to stoichiometric-based models, the development of large-scale kinetic models of metabolism has been hindered by the challenge of identifying kinetic parameter values and kinetic rate laws applicable to a wide range of environmental and/or genetic perturbations. The recently introduced ensemble modeling (EM) procedure provides a promising remedy to address these challenges by decomposing metabolic...
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