Article
Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk Factors for Hypospadias.
The Journal of urology - 1 Feb 2019
Kojima Yoshiyuki, Koguchi Tomoyuki, Mizuno Kentaro, Sato Yuichi, Hoshi Seiji, Hata Junya, Nishio Hidenori, Hashimoto Daiki, Matsushita Shoko, Suzuki Kentaro, Miyagawa Shinichi, Hui Chi Chung, Tanikawa Chizu, Murakami Yoshimori, Yamada Gen, Hayashi Yutaro, Matsuda Koichi
Abstract excerpt
PURPOSE: We evaluated the association of hypospadias and 17 susceptibility loci previously identified by a European genome-wide association study in a cohort of Japanese patients. We also examined the expression of candidate genes in male mouse embryos to determine the possible underlying mechanisms of this disease. MATERIALS AND METHODS: We enrolled 169 Japanese patients (mean age at surgery 3.7 years) who...
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