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Increased hypospadias risk by GREM1 rs3743104[G] in the southern Han Chinese population.

Aging - 7 May 2021

Deng Fuming, Zhao Jinglu, Jia Wei, Fu Kai, Zuo Xiaoyu, Huang Lihua, Wang Ning, Xia Huiming, Zhang Yan, Fu Wen, Liu Guochang

Abstract excerpt

Hypospadias is a common congenital genitourinary malformation characterized by ventral opening of the urethral meatus. As a member of the bone morphogenic protein antagonist family, GREM1 has been identified as associated with susceptibility to hypospadias in the European population. The present study was designed to elaborate on the mutual relationship between replicated single-nucleotide polymorphisms (SNPs)...

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PMID: 33962391
DOI: 10.18632/aging.202983
PMCID: PMC8202882

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