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Article

Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans.

eLife - 31 Jul 2018

Chen Xi, Shibata Akihiro Ce, Hendi Ardalan, Kurashina Mizuki, Fortes Ethan, Weilinger Nicholas L, MacVicar Brian A, Murakoshi Hideji, Mizumoto Kota

Abstract excerpt

During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Rap2 GTPase (rap-2) and its effector, TNIK (mig-15), act genetically downstream of Plexin (plx-1)...

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Identifiers

PMID: 30063210
DOI: 10.7554/eLife.38801
PMCID: PMC6067881

Genes

TNIK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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